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EURAMOS-1 is, to the top of our know-how, the main collaboration to evaluate in a randomised manner whether altering chemotherapy on the basis of histological reaction increases result for people with osteosarcoma. Our results for sufferers which has a lousy histological response show that the addition of ifosfamide and etoposide to straightforward postoperative therapy would not increase consequence and alternatively boosts the incidence of harmful results.

The protocol supplied suggestions for dose reductions on the basis of your toxicity (in the common toxicity requirements) and therapy delays.

A preceding randomised managed trial29 of about 240 patients assessed the addition of ifosfamide to plain MAP chemotherapy for clients with osteosarcoma.

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Pinealoblastoma is often a remarkably malignant embryonal tumour in the pineal location impacting children and younger adults. We herein intend to report the medical functions and therapy end result of clients of pinealoblastoma dealt with at our institute.

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Clients dealt with with MAP gained 29 weeks of therapy or four cycles of MAP and two cycles of methotrexate and doxorubicin (cisplatin was discontinued after a cumulative dose of 480 mg/m2).

Imaging suggestions all through cure involved a upper body CT, a bone scan, along with a plain radiograph of the principal tumour at 4-thirty day period intervals.

Nonetheless, the same system is much less productive in young small children and ground breaking review types of intensification of put up-operative therapy have to be explored On this age group.

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MRS and GJ had access to Uncooked data. The corresponding author experienced full use of all knowledge inside the research and all authors experienced final responsibility for the decision to submit for publication.

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